Endocrine Abstracts

Background: Hyponatraemia is a frequent finding in medical inpatients, where a comprehensive evaluation is warranted to establish the underlying mechanism and guide further management. Whilst the role of confounding medications, syndrome of inappropriate anti-diuretic hormone (SIADH), adrenal insufficiency and polydipsia is well-established as causative factors in the development of hyponatremia, the link between hypothyroidism and hyponatremia is controversial in the medical ...

Thyroid storm is a rare complication of thyrotoxicosis, life-threatening if not managed appropriately.We report a 43-year-old woman who presented to emergency services with shortness of breath, palpitations and weight loss. She was pale, cachectic, in atrial fibrillation and had signs of decompensated heart failure. Investigations showed: WBCs: 3.2×109/l, neutrophils 2.1×109/l, Hb 53 g/l, platelet 233, TSH <0.02 mIU/l, FT4 64 (10–25 pm...

Introduction: Alemtuzumab is humanized monoclonal antibody used in the treatment of relapsing–remitting multiple sclerosis (MS). The 5year incidence of thyroid adverse events in phase-3 clinical trials is up-to 40.7%. In most cases, the thyroid dysfunction is mild and easily manageable. Hyperthyroidism, particularly Graves’ disease (GD) is more common. We describe a case of unusual thyroid dysfunction in a patient treated with Alemtuzumab.Case:...

Background: Hypothyroidism is a common endocrine disorder. Common causes are autoimmune disease such as Hashimoto’ thyroiditis, surgical removal of the thyroid, drug induced and radioactive iodine (RAI) ablation.Aim: The aim of our study was to determine the etiology of hypothyroidism in Nepalese patients.Method: This is a retrospective study conducted in our opd from May 2015 to April 2019 in which data was collected from th...

Background: Thyroid nodules are common with annual increasing trends worldwide. 5% to 15% of the thyroid nodules is thyroid cancer. The prevalence of thyroid nodule is 3%–7% prevalence by palpation and 19%–67% by high resolution ultrasound. Thyroid nodules are more prevalent in women and older age group. More than 95% of all thyroid nodules are benign.Aim: The aim of this study is to assess the clinical profile of patients with solitary thyro...

Background: Thyroid cancer is the most common malignant disease of the endocrine system. Thyroid cancer represents above 1% of all malignancies. There is a paucity of data on thyroid cancer in Nepalese patients.Aim: The aim of this study is to explore clinical profile of thyroid cancer patients diagnosed and managed in our center.Methods: A total of 70 patients with thyroid cancer were included in the sample from March 2013 to Dece...

Introduction: Tolvaptan is an oral vasopressin V2 receptor antagonist which offers a novel treatment for euvolaemic and hypervolaemic hyponatraemia. Here, we report our experience with Tolvaptan in elderly patients.Case 1: Seventy sex-year-old lady with background of hypothyroidism, hypertension and alcohol excess presented with acute onset of confusion. Her admission Sodium [Na+] level was 117 mmol/l and represented an acute drop f...

A 62-year-old man presented with 1 month history of lethargy, nocturia, thirst and diplopia. On examination he had left 3rd nerve palsy with complete ptosis. MRI pituitary demonstrated a 1.3×1.1 cm enhancing mass on the left side of the pituitary gland, with invasion of the left cavernous sinus. Endocrine work up revealed partial DI, TSH and gonadotrophin deficiency. Because of unusual appearance of the pituitary lesions, a biopsy was arranged but initial histology was in...

ObjectThe aim of the study was to evaluate the peripartum changes in the level of TSH and thyroid function, due to dietary iron deficiency anaemia. Iron deficiency anaemia is widely prevalent in developing countries like India. It is the most pervasive of all nutritional deficiencies, particularly affecting women especially pregnant women. It is very important to note the changes in the thyroid activity by severe anaemia during peripartum period.<p c...

A 60 year old pest control worker presented to the dermatologists with a 3-month history of progressive thickening and change in texture of skin lesions affecting the face, lips and eyelids. Histology revealed papular mucinosis/lichen myxoedematosus and he was treated with plasma exchange, high dose steroids and cyclophosphamide. Investigations for associated tiredness, four months following presentation and initiation of therapy revealed impaired GH and cortisol responses to ...